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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November is the most popular month to cruise between USA and Panama and there are 25 departures available from nine of the world's leading cruise lines.
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20 Cruises (25 Cruise Departures)
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 23 March 2025
Countries Visited: USA, Bahamas, Mexico, Guatemala (+4 more), Belize, Honduras, Costa Rica, Panama
New Year Sale
INSIDE
$4,832
OCEANVIEW
$4,832
BALCONY
-
SUITE
-
From (per person) 4,832
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+2 more), Peru, Chile
Exclusive Deal
INSIDE
$3,900
OCEANVIEW
$4,296
BALCONY
$5,286
SUITE
$7,563
From (per person) 3,900
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$21,751
Save (per person) 324
From (per person) 15,871
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Countries Visited: USA, Bahamas, Jamaica, Panama (+2 more), Peru, Chile
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$16,851
SUITE
$23,711
Save (per person) 344
From (per person) 16,851
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,501
Save (per person) 144
From (per person) 6,561
View Trip
11 Day Passage To Panama with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$4,310
OCEANVIEW
$4,733
BALCONY
$7,018
SUITE
$9,737
Save (per person) 2,250
From (per person) 4,310
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 08 February 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,287
OCEANVIEW
$5,663
BALCONY
-
SUITE
-
Save (per person) 2,033
From (per person) 5,287
View Trip
13 Day Majestic Beaches & Canal Crossing with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 03 January 2026
Countries Visited: USA, Cayman Islands, Jamaica, Bonaire (+5 more), Curacao, Aruba, Colombia, Costa Rica, Panama
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,027
SUITE
$13,175
Save (per person) 5,863
From (per person) 13,027
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$18,805
SUITE
$19,171
Save (per person) 7,105
From (per person) 18,805
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$30,825
SUITE
$38,651
Save (per person) 5,610
From (per person) 30,825
View Trip
12 Day San Diego to Panama City with Silversea
Cruise

12 Days (11 Nights) San Diego to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
$8,019
BALCONY
$9,207
SUITE
-
From (per person) 8,019
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
New Year Sale
INSIDE
$5,587
OCEANVIEW
$5,587
BALCONY
$6,716
SUITE
$12,804
From (per person) 5,587
View Trip
23 Day Palms To Andean Peaks with Oceania Cruises
Cruise

23 Days (22 Nights) Miami to Santiago
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+6 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
New Year Sale
INSIDE
$8,459
OCEANVIEW
$10,557
BALCONY
$10,557
SUITE
$17,923
From (per person) 8,459
View Trip
23 Day Atlantic Crossing & Panama Canal Passage with Seabourn
Cruise

23 Days (22 Nights) Lisbon to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 20 November 2025
Countries Visited: Portugal, Bermuda, USA, Bonaire (+3 more), Curacao, Colombia, Panama
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$11,222
SUITE
$19,806
From (per person) 11,222
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,684
OCEANVIEW
$5,139
BALCONY
$7,545
SUITE
$10,396
Save (per person) 2,026
From (per person) 4,684
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+3 more), Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$4,542
OCEANVIEW
$4,691
BALCONY
$5,958
SUITE
$6,552
From (per person) 4,542
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$13,330
SUITE
$13,617
Save (per person) 7,060
From (per person) 13,330
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Tampa to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 29 January 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+3 more), Colombia, Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$4,315
SUITE
$6,176
From (per person) 4,315
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Countries Visited: USA, Bonaire, Curacao, Colombia (+1 more), Panama
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$6,739
SUITE
$11,577
From (per person) 6,739
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,309
OCEANVIEW
$4,733
BALCONY
$7,018
SUITE
$9,737
Save (per person) 2,251
From (per person) 4,309
View Trip
Results: 20 results

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