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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 25 departures available from ten of the world's leading cruise lines.
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15 Days
128 Days
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$1,300pp
$162,180pp
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24 Cruises (25 Cruise Departures)
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Exclusive Deal
INSIDE
$2,849
OCEANVIEW
-
BALCONY
$3,505
SUITE
$4,829
From (per person) 2,849
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Exclusive Deal
INSIDE
$13,580
OCEANVIEW
$14,937
BALCONY
$20,649
SUITE
$28,618
Save (per person) 2,090
From (per person) 13,580
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 22 March 2025
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$2,566
OCEANVIEW
$2,704
BALCONY
$2,962
SUITE
$3,655
From (per person) 2,566
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (7)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Mar 2025 to Feb 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,073
SUITE
$19,498
Save (per person) 970
From (per person) 12,073
View Trip
21 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (2)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 March 2026
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$3,490
OCEANVIEW
$3,877
BALCONY
$4,626
SUITE
$5,857
From (per person) 3,490
View Trip
22 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 18 February 2025
Countries Visited: USA, Portugal, Spain, Gibraltar (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$2,961
OCEANVIEW
-
BALCONY
$3,664
SUITE
$4,199
From (per person) 2,961
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
$1,847
OCEANVIEW
$2,511
BALCONY
$2,183
SUITE
$2,986
From (per person) 1,847
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) New York to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 31 March 2025
Countries Visited: USA, Portugal, Spain, France (+1 more), Italy
INSIDE
$2,304
OCEANVIEW
-
BALCONY
$3,023
SUITE
$3,481
From (per person) 2,304
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
New Year SaleExclusive Deal
INSIDE
$2,176
OCEANVIEW
-
BALCONY
$4,654
SUITE
$21,715
Save (per person) 1,396
From (per person) 2,176
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$7,997
OCEANVIEW
$9,353
BALCONY
$10,551
SUITE
$14,917
Save (per person) 2,053
From (per person) 7,997
View Trip
16 Day Spanish Passage with Princess
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 March 2025
Countries Visited: USA, Portugal, Gibraltar, Spain (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$1,324
OCEANVIEW
$1,642
BALCONY
$1,978
SUITE
$2,908
From (per person) 1,324
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$22,473
From (per person) 22,473
View Trip
17 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Exclusive DealNew Year Sale
INSIDE
-
OCEANVIEW
$2,382
BALCONY
$3,267
SUITE
$8,105
Save (per person) 1,515
From (per person) 2,382
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Miami to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 06 April 2025
Countries Visited: USA, Sint Maarten, Antigua and Barbuda, Barbados (+4 more), Portugal, Spain, Sicily, Italy
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$5,236
From (per person) 5,236
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+1 more), Italy
Early Booking Offer
INSIDE
$2,398
OCEANVIEW
$2,695
BALCONY
$2,982
SUITE
$4,547
From (per person) 2,398
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
Sail Of The Year
INSIDE
-
OCEANVIEW
$11,803
BALCONY
$13,654
SUITE
$19,797
From (per person) 11,803
View Trip
21 Day Atlantic Crossing: Miami To The Mediterranean with Seabourn
Cruise

21 Days (20 Nights) Miami to Rome
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 28 April 2025
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$12,113
SUITE
-
From (per person) 12,113
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive DealNew Year Sale
INSIDE
$1,717
OCEANVIEW
$2,014
BALCONY
$2,350
SUITE
$7,358
Save (per person) 1,001
From (per person) 1,717
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Miami to Florence
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 06 April 2025
Countries Visited: USA, Saint Martin, Antigua and Barbuda, Barbados (+4 more), Portugal, Spain, Sicily, Italy
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$4,081
SUITE
$5,507
From (per person) 4,081
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 27 April 2025
Countries Visited: USA, Portugal, Spain, Italy
Exclusive Deal
INSIDE
$3,248
OCEANVIEW
-
BALCONY
$4,283
SUITE
$25,731
Save (per person) 1,580
From (per person) 3,248
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
New Year SaleExclusive Deal
INSIDE
$2,473
OCEANVIEW
$2,845
BALCONY
$3,235
SUITE
$8,257
Save (per person) 1,536
From (per person) 2,473
View Trip
17 Day Treasures Of The Atlantic with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 15 April 2027
Countries Visited: USA, Bermuda, Spain, Corsica (+1 more), Italy
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$15,095
SUITE
$15,610
Save (per person) 7,085
From (per person) 15,095
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+33 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, Nicaragua, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$122,800
SUITE
$136,096
Save (per person) 39,380
From (per person) 122,800
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$5,742
SUITE
$9,880
Save (per person) 2,338
From (per person) 5,742
View Trip
Results: 24 results

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Cruises from USA to Italy

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