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Cruises From Santiago

Choose from 57 unique expeditions and cruises starting in Santiago, and travelling to Broome, Buenos Aires, Cape Town, Darwin, Fort Lauderdale and more. February is the most popular month to join a cruise from Santiago and you can select from 165 departures available from fourteen leading cruise lines.
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7 Days
58 Days
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57 Cruises (165 Cruise Departures)
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Feb 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,775
SUITE
$19,791
Save (per person) 356
From (per person) 10,775
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$4,099
OCEANVIEW
$4,544
BALCONY
$5,584
SUITE
$7,861
From (per person) 4,099
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: Chile, Argentina
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,568
SUITE
$17,815
Save (per person) 2,427
From (per person) 12,568
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$7,355
OCEANVIEW
$8,177
BALCONY
$10,592
SUITE
$16,117
From (per person) 7,355
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$22,731
Save (per person) 324
From (per person) 15,871
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,552
OCEANVIEW
$3,938
BALCONY
$5,384
SUITE
$6,869
From (per person) 3,552
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,457
OCEANVIEW
$3,853
BALCONY
$5,289
SUITE
$6,972
From (per person) 3,457
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 21 December 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$29,799
BALCONY
$35,343
SUITE
$52,074
Save (per person) 2,801
From (per person) 29,799
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 19 December 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$41,780
Save (per person) 830
From (per person) 41,780
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Santiago
Ship: MS Fram
Departures: Feb 2025 to Jan 2027
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Wave Offer
INSIDE
-
OCEANVIEW
$28,186
BALCONY
-
SUITE
$37,488
Save (per person) 4,170
From (per person) 28,186
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Eclipse II
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Antarctica, Argentina
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$51,660
SUITE
$61,622
Save (per person) 5,499
From (per person) 51,660
View Trip
58 Day Remote Islands Of The Pacific & Kimberley Expedition with Seabourn
Cruise

58 Days (57 Nights) Santiago to Broome
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Pitcairn Islands, French Polynesia, Cook Islands (+7 more), Samoa, Tonga, Fiji, Vanuatu, Papua New Guinea, Indonesia, Australia
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$70,335
SUITE
$101,049
From (per person) 70,335
View Trip
41 Day Puerto Williams to Cape Town with Silversea
Cruise

41 Days (40 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 22 February 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica (+2 more), Saint Helena, South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$55,242
SUITE
$90,783
From (per person) 55,242
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Mar 2026 to Dec 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,839
BALCONY
$25,839
SUITE
$36,630
Save (per person) 2,775
From (per person) 25,839
View Trip
17 Day Edge Of The World Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 01 February 2026
Countries Visited: Chile, Argentina, Uruguay
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$18,793
SUITE
$19,387
Save (per person) 6,967
From (per person) 18,793
View Trip
10 Day Puerto Williams to King George Island with Silversea
Cruise

10 Days (9 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Jan 2027 to Mar 2027
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,087
BALCONY
$26,136
SUITE
$43,362
Save (per person) 4,228
From (per person) 21,087
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Jan 2025 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$24,849
BALCONY
$24,849
SUITE
$44,550
Save (per person) 4,268
From (per person) 24,849
View Trip
30 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour + Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Ship: Delfin III
Departure: 12 September 2025
Trip Styles: Coach, Cruise, River Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$40,052
Save (per person) 2,343
From (per person) 40,052
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
Exclusive Deal
INSIDE
$14,088
OCEANVIEW
$15,138
BALCONY
$28,146
SUITE
$52,649
From (per person) 14,088
View Trip
31 Day Chilean Fjords, Glaciers & Antarctic Wildlife Explorer with Scenic
Cruise

31 Days (30 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina, Falkland Islands, South Georgia Island (+1 more), Antarctica
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$63,025
SUITE
$79,449
Save (per person) 16,085
From (per person) 63,025
View Trip
23 Day Puerto Williams to Cape Town with Silversea
Cruise

23 Days (22 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 12 March 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Saint Helena (+1 more), South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,830
BALCONY
$17,325
SUITE
$24,651
Save (per person) 2,670
From (per person) 16,830
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$39,974
SUITE
$42,463
Save (per person) 811
From (per person) 39,974
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$25,180
SUITE
$35,783
From (per person) 25,180
View Trip
26 Day South American Discovery with Santiago Stopover & Galápagos Cruise with Globus
Tour + Cruise

26 Days Santiago to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
Save (per person) 552
From (per person) 19,611
View Trip
48 Day Remote Islands Of The Pacific & New Guinea with Seabourn
Cruise

48 Days (47 Nights) Santiago to Darwin
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+8 more), Cook Islands, Samoa, Tonga, Fiji, Vanuatu, Papua New Guinea, Indonesia, Australia
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$55,169
SUITE
$78,395
From (per person) 55,169
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Exclusive Deal
INSIDE
$10,407
OCEANVIEW
$14,862
BALCONY
$17,139
SUITE
$31,494
From (per person) 10,407
View Trip
20 Day Ushuaia & The White Continent with Regent Seven Seas
Cruise

20 Days (19 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 February 2025
Countries Visited: Chile, Argentina, Antarctica, Falkland Islands (+1 more), Uruguay
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$20,864
SUITE
$21,597
Save (per person) 8,036
From (per person) 20,864
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 December 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,839
BALCONY
$29,304
SUITE
$37,719
Save (per person) 2,761
From (per person) 25,839
View Trip
29 Day Ultimate South America with Santiago Stopover & Galapagos Cruise with Cosmos
Tour + Cruise

29 Days Santiago to Guayaquil
Operated By: Cosmos
Departures: Apr 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
Save (per person) 267
From (per person) 16,316
View Trip
32 Day Across Oceanic Cultures: Chilean Coast To Fiji with Seabourn
Cruise

32 Days (31 Nights) Santiago to Lautoka
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+4 more), Cook Islands, Samoa, Tonga, Fiji
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$37,228
SUITE
$51,365
From (per person) 37,228
View Trip
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