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Panama Cruises

Are you looking for a cruise to Panama? Choose from 85 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, London, Los Angeles and more. January is the most popular month to cruise to Panama and we have over 132 departures available from sixteen of the world's leading cruise lines.
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85 Cruises (132 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 23 February 2025
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$13,225
SUITE
-
Save (per person) 255
From (per person) 13,225
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$8,343
SUITE
$10,778
Save (per person) 3,052
From (per person) 8,343
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departure: 05 March 2025
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$32,286
Save (per person) 644
From (per person) 32,286
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
From (per person) 14,190
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,402
SUITE
$19,174
Save (per person) 265
From (per person) 12,402
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive Deal
INSIDE
$155
OCEANVIEW
$199
BALCONY
$223
SUITE
$321
Save (per person) 188
From (per person) 155
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 February 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,203
SUITE
$13,809
Save (per person) 157
From (per person) 8,203
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,540
SUITE
$18,086
Save (per person) 200
From (per person) 10,540
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2025 to Feb 2026
Countries Visited: Costa Rica, Panama
From (per person) 13,590
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,527
SUITE
$11,153
Save (per person) 123
From (per person) 6,527
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$6,959
SUITE
$11,908
Save (per person) 152
From (per person) 6,959
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Circle Club Voyage
INSIDE
$7,658
OCEANVIEW
$8,390
BALCONY
$10,638
SUITE
$13,875
From (per person) 7,658
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$15,981
SUITE
$18,842
Save (per person) 6,634
From (per person) 15,981
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$7,128
BALCONY
$8,019
SUITE
-
From (per person) 7,128
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$10,468
SUITE
$12,844
Save (per person) 3,577
From (per person) 10,468
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,126
SUITE
$9,810
Save (per person) 114
From (per person) 6,126
View Trip
20 Day New York To San Francisco with Cunard
Cruise
 (3)

20 Days (19 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 18 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$6,243
OCEANVIEW
$9,708
BALCONY
$9,906
SUITE
-
From (per person) 6,243
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,249
OCEANVIEW
$1,382
BALCONY
$1,475
SUITE
$1,974
Save (per person) 825
From (per person) 1,249
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,124
OCEANVIEW
$1,238
BALCONY
$1,484
SUITE
$2,320
Save (per person) 779
From (per person) 1,124
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,531
OCEANVIEW
$1,637
BALCONY
$1,850
SUITE
$2,696
Save (per person) 902
From (per person) 1,531
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Bonaire, Aruba, Panama
Exclusive DealSingle Savings
INSIDE
$1,377
OCEANVIEW
$1,448
BALCONY
$1,595
SUITE
$2,414
Save (per person) 912
From (per person) 1,377
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Countries Visited: USA, Aruba, Panama, Mexico
Exclusive Deal
INSIDE
$2,568
OCEANVIEW
$3,529
BALCONY
$4,964
SUITE
$7,043
From (per person) 2,568
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Colombia, Bonaire, Curacao, Panama
Exclusive Deal
INSIDE
$1,513
OCEANVIEW
$1,575
BALCONY
$1,765
SUITE
$2,114
Save (per person) 900
From (per person) 1,513
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,254
OCEANVIEW
$1,370
BALCONY
$1,542
SUITE
$2,251
Save (per person) 770
From (per person) 1,254
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 21 December 2025
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealSingle Savings
INSIDE
$1,766
OCEANVIEW
$1,908
BALCONY
$2,099
SUITE
$3,848
Save (per person) 1,013
From (per person) 1,766
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,250
OCEANVIEW
$1,401
BALCONY
$1,661
SUITE
$2,356
Save (per person) 829
From (per person) 1,250
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$30,825
SUITE
$38,651
Save (per person) 5,610
From (per person) 30,825
View Trip
12 Day San Diego to Panama City with Silversea
Cruise

12 Days (11 Nights) San Diego to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
$8,019
BALCONY
$9,207
SUITE
-
From (per person) 8,019
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealSingle Savings
INSIDE
$1,378
OCEANVIEW
$1,521
BALCONY
$1,782
SUITE
$2,117
Save (per person) 1,126
From (per person) 1,378
View Trip
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Travel Styles

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Trip Lengths

3 Week

Departure Months

January 2025 February 2025 March 2025 April 2025 May 2025 September 2025 October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 May 2026 September 2026 October 2026 November 2026 December 2026 January 2027 February 2027 March 2027 April 2027

Cities

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Routes

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Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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