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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 37 departures available from twelve of the world's leading cruise lines.
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58 Days
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37 Cruises (37 Cruise Departures)
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive Deal
INSIDE
$2,052
OCEANVIEW
$3,120
BALCONY
$2,704
SUITE
$3,862
From (per person) 2,052
View Trip
15 Day Cultural Crossing With Andalusia And Azores with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$1,843
OCEANVIEW
$1,942
BALCONY
$2,090
SUITE
$4,070
From (per person) 1,843
View Trip
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,073
SUITE
$18,211
Save (per person) 922
From (per person) 12,073
View Trip
27 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive Deal
INSIDE
$5,461
OCEANVIEW
$6,649
BALCONY
$8,233
SUITE
$11,668
From (per person) 5,461
View Trip
16 Day Transatlantic Crossing And Mediterranean Highlights with Cunard
Cruise
 (3)

16 Days (15 Nights) Rome to New York
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 20 April 2025
Countries Visited: Italy, Sardinia, Spain, England (+2 more), France, USA
Exclusive Deal
INSIDE
$4,211
OCEANVIEW
-
BALCONY
-
SUITE
-
From (per person) 4,211
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive Deal
INSIDE
$4,014
OCEANVIEW
$6,265
BALCONY
$5,937
SUITE
$7,335
From (per person) 4,014
View Trip
22 Day Western Mediterranean & Trans-Atlantic Crossing with Princess
Cruise
 (4)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 11 April 2025
Countries Visited: Italy, Corsica, France, Spain (+2 more), Morocco, USA
Exclusive Deal
INSIDE
$3,912
OCEANVIEW
$4,069
BALCONY
$4,376
SUITE
$6,218
From (per person) 3,912
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Countries Visited: Italy, Sardinia, Spain, Portugal (+2 more), Bermuda, USA
New Year SaleExclusive Deal
INSIDE
$2,325
OCEANVIEW
$2,752
BALCONY
$3,361
SUITE
$8,424
Save (per person) 1,522
From (per person) 2,325
View Trip
15 Day Splendid Atlantic Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 18 May 2027
Countries Visited: Italy, Spain, Morocco, Bermuda (+1 more), USA
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,323
SUITE
$13,758
Save (per person) 7,067
From (per person) 13,323
View Trip
26 Day A Grand Journey Of European Gems And Tropical Idylls with Explora Journeys
Cruise

26 Days (25 Nights) Venice to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 18 October 2025
Countries Visited: Italy, Croatia, Montenegro, Monaco (+6 more), Spain, Portugal, Antigua and Barbuda, Virgin Islands, Puerto Rico, USA
Unique Oceans Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$19,379
SUITE
$20,785
From (per person) 19,379
View Trip
23 Day Mediterranean with MSC Cruises
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$3,301
OCEANVIEW
$3,598
BALCONY
$4,361
SUITE
$6,578
From (per person) 3,301
View Trip
22 Day Riviera Gems & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 11 November 2025
Countries Visited: Italy, Corsica, Sardinia, Spain (+3 more), Portugal, Bermuda, USA
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$10,621
SUITE
$36,758
From (per person) 10,621
View Trip
36 Day MSC Grand Voyages with MSC Cruises
Cruise

36 Days (35 Nights) Rome to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Early Booking Offer
INSIDE
$5,248
OCEANVIEW
$5,842
BALCONY
$7,396
SUITE
-
From (per person) 5,248
View Trip
22 Day Mediterranean with MSC Cruises
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,996
OCEANVIEW
$3,442
BALCONY
$4,164
SUITE
$6,313
From (per person) 2,996
View Trip
33 Day Adriatic To Caribbean Isles with Oceania Cruises
Cruise

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$12,380
OCEANVIEW
$13,875
BALCONY
$19,438
SUITE
$26,358
Save (per person) 2,080
From (per person) 12,380
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Early Booking Offer
INSIDE
$2,013
OCEANVIEW
$2,340
BALCONY
$3,102
SUITE
$6,637
From (per person) 2,013
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$9,959
OCEANVIEW
$12,207
BALCONY
$14,167
SUITE
$19,127
Save (per person) 2,071
From (per person) 9,959
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+2 more), Bermuda, USA
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,215
SUITE
$10,878
Save (per person) 7,185
From (per person) 10,215
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Early Booking Offer
INSIDE
$2,153
OCEANVIEW
$2,480
BALCONY
$2,836
SUITE
$6,341
From (per person) 2,153
View Trip
57 Day Antiquity To America with Oceania Cruises
Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$31,946
SUITE
$46,074
Save (per person) 2,254
From (per person) 31,946
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,019
SUITE
$18,979
Save (per person) 2,111
From (per person) 14,019
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Early Booking Offer
INSIDE
$3,004
OCEANVIEW
$3,301
BALCONY
$3,737
SUITE
-
From (per person) 3,004
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Early Booking Offer
INSIDE
$1,916
OCEANVIEW
$2,232
BALCONY
$2,698
SUITE
$6,272
From (per person) 1,916
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+2 more), Portugal, USA
Sail Of The Year
INSIDE
-
OCEANVIEW
$11,380
BALCONY
$13,483
SUITE
$20,468
From (per person) 11,380
View Trip
22 Day Transatlantic with MSC Cruises
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,897
OCEANVIEW
$3,283
BALCONY
$4,164
SUITE
$6,263
From (per person) 2,897
View Trip
26 Day Rome to Fort Lauderdale with Silversea
Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,622
From (per person) 17,622
View Trip
31 Day A Journey Of Sun And Sea with Regent Seven Seas
Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Upgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$28,848
SUITE
$31,066
Save (per person) 13,912
From (per person) 28,848
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$22,337
OCEANVIEW
$24,594
BALCONY
$34,662
SUITE
$48,047
Save (per person) 2,143
From (per person) 22,337
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,405
SUITE
$16,435
Save (per person) 8,275
From (per person) 15,405
View Trip
17 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
New Year SaleExclusive Deal
INSIDE
$2,355
OCEANVIEW
$2,663
BALCONY
$4,175
SUITE
$25,297
Save (per person) 1,473
From (per person) 2,355
View Trip
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