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Cruises From Colon

Choose from 22 unique cruises starting in Colon, and travelling to Cancun, Cartagena, Fort-de-France, Los Angeles and Puntarenas. January is the most popular month to join a cruise from Colon and you can select from 39 departures available from three leading cruise lines.
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22 Cruises (39 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,249
OCEANVIEW
$1,382
BALCONY
$1,475
SUITE
$1,974
Save (per person) 825
From (per person) 1,249
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 23 February 2025
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$13,225
SUITE
-
Save (per person) 255
From (per person) 13,225
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,124
OCEANVIEW
$1,238
BALCONY
$1,484
SUITE
$2,320
Save (per person) 779
From (per person) 1,124
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,531
OCEANVIEW
$1,637
BALCONY
$1,850
SUITE
$2,696
Save (per person) 902
From (per person) 1,531
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
11 Day A Tropical Odyssey in Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Cancun
Cruise Line: Ponant
Ship: Le Champlain
Departure: 03 December 2025
Countries Visited: Panama, Costa Rica, Colombia, Honduras (+3 more), Guatemala, Belize, Mexico
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$11,103
SUITE
$17,051
Save (per person) 207
From (per person) 11,103
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive Deal
INSIDE
$1,550
OCEANVIEW
$1,611
BALCONY
$1,784
SUITE
$2,332
Save (per person) 898
From (per person) 1,550
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,254
OCEANVIEW
$1,370
BALCONY
$1,542
SUITE
$2,251
Save (per person) 770
From (per person) 1,254
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,250
OCEANVIEW
$1,401
BALCONY
$1,661
SUITE
$2,356
Save (per person) 829
From (per person) 1,250
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,402
SUITE
$19,174
Save (per person) 265
From (per person) 12,402
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive Deal
INSIDE
$155
OCEANVIEW
$199
BALCONY
$223
SUITE
$321
Save (per person) 188
From (per person) 155
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,196
OCEANVIEW
$1,272
BALCONY
$1,456
SUITE
$2,245
Save (per person) 1,015
From (per person) 1,196
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,249
OCEANVIEW
$1,322
BALCONY
$1,528
SUITE
$2,268
Save (per person) 873
From (per person) 1,249
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,114
Save (per person) 913
From (per person) 2,033
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,271
OCEANVIEW
$1,354
BALCONY
$1,498
SUITE
$1,974
Save (per person) 878
From (per person) 1,271
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,664
OCEANVIEW
$1,814
BALCONY
$2,075
SUITE
$2,901
Save (per person) 961
From (per person) 1,664
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 16 January 2026
Countries Visited: Panama, Colombia, Curacao, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,573
SUITE
$15,325
Save (per person) 177
From (per person) 9,573
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,432
OCEANVIEW
$1,445
BALCONY
$1,491
SUITE
$2,292
Save (per person) 853
From (per person) 1,432
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,527
SUITE
$11,153
Save (per person) 123
From (per person) 6,527
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
New Year Sale
INSIDE
$5,584
OCEANVIEW
$5,584
BALCONY
$6,713
SUITE
$12,801
From (per person) 5,584
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Bellot
Departure: 15 March 2025
Countries Visited: Panama, Colombia, Holland, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$14,394
SUITE
$24,518
Save (per person) 276
From (per person) 14,394
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive Deal
INSIDE
$1,268
OCEANVIEW
$1,337
BALCONY
$1,562
SUITE
$2,047
Save (per person) 795
From (per person) 1,268
View Trip
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