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Royal Caribbean Cruises from Colon

Start your journey from Colon with 14 unique Royal Caribbean cruise itineraries to choose from. December, January and March are the most popular months to begin your cruise from Colon and Royal Caribbean have 29 trips departing this season.
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2 Days
11 Days
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$100pp
$2,946pp
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14 Cruises (29 Cruise Departures)
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,114
Save (per person) 913
From (per person) 2,033
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,124
OCEANVIEW
$1,238
BALCONY
$1,484
SUITE
$2,320
Save (per person) 779
From (per person) 1,124
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,664
OCEANVIEW
$1,814
BALCONY
$2,075
SUITE
$2,901
Save (per person) 961
From (per person) 1,664
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,432
OCEANVIEW
$1,445
BALCONY
$1,491
SUITE
$2,292
Save (per person) 853
From (per person) 1,432
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,249
OCEANVIEW
$1,322
BALCONY
$1,528
SUITE
$2,268
Save (per person) 873
From (per person) 1,249
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,254
OCEANVIEW
$1,370
BALCONY
$1,542
SUITE
$2,251
Save (per person) 770
From (per person) 1,254
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,249
OCEANVIEW
$1,382
BALCONY
$1,475
SUITE
$1,974
Save (per person) 825
From (per person) 1,249
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,196
OCEANVIEW
$1,272
BALCONY
$1,456
SUITE
$2,245
Save (per person) 1,015
From (per person) 1,196
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive Deal
INSIDE
$155
OCEANVIEW
$199
BALCONY
$223
SUITE
$321
Save (per person) 188
From (per person) 155
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive Deal
INSIDE
$1,550
OCEANVIEW
$1,611
BALCONY
$1,784
SUITE
$2,332
Save (per person) 898
From (per person) 1,550
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive Deal
INSIDE
$1,268
OCEANVIEW
$1,337
BALCONY
$1,562
SUITE
$2,047
Save (per person) 795
From (per person) 1,268
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,271
OCEANVIEW
$1,354
BALCONY
$1,498
SUITE
$1,974
Save (per person) 878
From (per person) 1,271
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,250
OCEANVIEW
$1,401
BALCONY
$1,661
SUITE
$2,356
Save (per person) 829
From (per person) 1,250
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,531
OCEANVIEW
$1,637
BALCONY
$1,850
SUITE
$2,696
Save (per person) 902
From (per person) 1,531
View Trip
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